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Ocuphire Pharma
Ocuphire Pharma
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Trade Name
Drug Name
Approved
Patent Expires
Indication
Ryzumvi
Phentolamine
2023-09-25
2034-2039
Necrosis
,
Extravasation of diagnostic and therapeutic materials
,
Malignant hypertension
Clinical Trials
Therapeutic Areas:
All
Classification:
All
Approval:
All
Status:
All
Phases:
All
Drug Name
Phase 1
Phase 2
Phase 3
Phase 4
Indication
Phentolamine
obesity
,
healthy volunteers/patients
,
heart failure
,
type 1 diabetes mellitus
,
hypoglycemia
,
chronic obstructive pulmonary disease
,
pulmonary arterial hypertension
,
familial primary pulmonary hypertension
,
vasculogenic impotence
,
stem cell transplantation
,
insulin resistance
,
cardiovascular diseases
,
obstructive sleep apnea
,
sleep apnea syndromes
,
menopause
,
erectile dysfunction
,
prostatic neoplasms
,
ocular hypertension
,
glaucoma
,
open-angle glaucoma
,
hypesthesia
,
hypertension
,
pathologic dilatation
,
dilatation
,
mydriasis
,
presbyopia
,
drug-related side effects and adverse reactions
,
vitamin a deficiency
,
ischemic stroke
,
soft tissue injuries
,
acute kidney injury
,
wounds and injuries
,
acute coronary syndrome
,
coronary artery disease
,
mesopic vision
,
vision disorders
,
vasodilation
,
dental anesthesia
,
local anesthesia
,
vasoconstriction
,
pre-eclampsia
,
multiple myeloma
,
plasma cell neoplasms
,
neoplasm metastasis
,
pregnancy complications
,
eclampsia
,
stroke
,
cerebral hemorrhage
,
pneumonia
,
community-acquired pneumonia
,
intracranial hemorrhages
,
hemorrhage
,
diabetes mellitus
,
inflammation
,
hypotension
,
preoperative period
,
pathologic constriction
,
miosis
ERENAPURSTAT
macular edema
,
retinal diseases
,
diabetic retinopathy
Demand
cognitive dysfunction
,
type 1 diabetes mellitus
,
parkinson disease
,
autism spectrum disorder
,
substance-related disorders
,
contraception
,
anemia
,
melanoma
,
tobacco use
,
ear diseases
,
vitiligo
,
pulmonary edema
,
hypercapnia
,
shock
,
cardiogenic shock
,
cluster headache
,
motivation
,
cannabis
,
pulmonary arterial hypertension
,
familial primary pulmonary hypertension
,
glioblastoma
,
glioma
,
hyperbilirubinemia
,
triple negative breast neoplasms
,
otitis media with effusion
,
extracorporeal membrane oxygenation
,
transfusion reaction
,
stroke
,
mental disorders
,
dementia
,
heart failure
,
alzheimer disease
,
malnutrition
,
syndrome
,
cigarette smoking
,
anesthesia
,
vaping
,
neoplasm metastasis
,
memory disorders
,
ocular motility disorders
,
critical illness
,
tobacco use disorder
,
varicose veins
,
marijuana abuse
,
acute kidney injury
,
kidney neoplasms
,
hyperglycemia
,
cholangiocarcinoma
,
thrombasthenia
,
colic
,
psychological sexual dysfunctions
,
aphasia
,
frontotemporal dementia
,
primary progressive aphasia
,
pick disease of the brain
,
cerebrovascular disorders
,
esophageal and gastric varices
,
nutrition disorders
,
infratentorial neoplasms
,
video-assisted thoracic surgery
,
antineoplastic combined chemotherapy protocols
,
plasmacytoma
,
hemostasis
,
keratoconjunctivitis
,
eye diseases
,
hypokinesia
,
abdominal pain
,
oropharyngeal neoplasms
,
marijuana smoking
,
marijuana use
,
lymphoma
,
amnesia
,
immunotherapy
,
depression
,
hiv infections
,
carcinoma
,
anxiety disorders
,
low back pain
,
hemorrhage
,
obesity
,
back pain
,
chronic obstructive pulmonary disease
,
neoplasms
,
chronic pain
,
type 2 diabetes mellitus
,
lung diseases
,
smoking cessation
,
blood coagulation disorders
,
obstructive lung diseases
,
post-traumatic stress disorders
,
acquired immunodeficiency syndrome
,
acute pain
,
von willebrand diseases
,
alcoholism
,
opioid-related disorders
,
prostatic neoplasms
,
labor pain
,
hereditary angioedemas
,
caregiver burden
,
traumatic stress disorders
,
angioedema
,
analgesia
,
agnosia
,
arthritis
,
psychological distress
,
afibrinogenemia
,
pain management
,
hemorrhagic disorders
,
multiple myeloma
,
headache
,
medication adherence
,
coagulation protein disorders
,
leukemia
,
chronic urticaria
,
urticaria
,
ureterolithiasis
,
sickle cell anemia
,
peptic esophagitis
,
female genital neoplasms
,
overweight
,
hereditary angioedema types i and ii
,
feeding behavior
,
obstructive sleep apnea
,
neuralgia
,
gouty arthritis
,
gout
,
inborn genetic diseases
,
homosexuality
,
plasma cell neoplasms
,
type 3 von willebrand disease
,
ureteral calculi
,
factor vii deficiency
,
polypharmacy
,
thrombotic thrombocytopenic purpura
,
child development
,
male circumcision
,
treatment adherence and compliance
,
hereditary angioedema type iii
,
sleep apnea syndromes
,
nociceptive pain
,
vision disorders
,
wet macular degeneration
,
x-linked genetic diseases
,
inherited blood coagulation disorders
,
breakthrough pain
,
subarachnoid hemorrhage
,
intraoperative complications
,
cancer pain
,
peptic ulcer
,
sjogren's syndrome
,
xerostomia
,
anesthesia and analgesia
,
highly active antiretroviral therapy
,
lacerations
,
growth disorders
,
hereditary autoinflammatory diseases
,
familial mediterranean fever
,
brucellosis
,
apnea
,
aplastic anemia
,
intractable pain
,
bone marrow failure disorders
,
mucositis
,
severe combined immunodeficiency
,
immune system diseases
,
thrombocytopenic purpura idiopathic
,
blood platelet disorders
,
autoimmune diseases
,
thrombocytopenic purpura
,
purpura
,
skin manifestations
,
cytopenia
,
immunoglobulin light-chain amyloidosis
,
factor x deficiency
,
hemophilia a
,
erectile dysfunction
,
hemophilia b
,
postoperative pain
,
hepatocellular carcinoma
,
pain
,
diabetes mellitus
,
liver neoplasms
,
healthy volunteers/patients
,
breast neoplasms
,
wounds and injuries
,
hiv
,
gastroesophageal reflux
,
premature birth
,
premature ejaculation
,
hypertension
,
aging
,
hemostatic disorders
,
spinal cord injuries
,
emergencies
,
osteoarthritis
,
respiratory insufficiency
,
nerve block
,
hematologic diseases
,
pregnancy
,
joint diseases
,
attention deficit disorder with hyperactivity
,
replacement arthroplasty knee
,
myocardial ischemia
,
asthma
,
local anesthesia
,
conduction anesthesia
,
respiratory aspiration
,
infections
,
bone fractures
,
ankylosing spondylitis
,
hepatitis c
,
esophageal neoplasms
,
patient-controlled analgesia
,
funnel chest
,
allergic rhinitis
,
diet therapy
,
heartburn
,
spondylarthritis
,
spondylitis
,
knee osteoarthritis
,
sexually transmitted diseases
,
physiological sexual dysfunction
,
communicable diseases
,
pneumonia
,
weight loss
,
hepatitis
,
hepatitis a
,
dry eye syndromes
,
behavior
,
insulin resistance
,
patient satisfaction
,
syphilis
,
macular degeneration
,
postoperative nausea and vomiting
,
vomiting
,
spinal anesthesia
,
fistula
,
neuromuscular blockade
,
postoperative period
,
morbid obesity
,
retinal vein occlusion
,
keratoconjunctivitis sicca
,
non-erosive reflux disease
,
aggression
,
rhinitis
,
brain neoplasms
,
irritable bowel syndrome
,
renal insufficiency
,
dyspepsia
,
gonorrhea
,
chlamydia infections
,
nausea
,
general anesthesia
,
hip fractures
,
uveitis
,
macular edema
,
bariatric surgery
,
orthopedic procedures
,
gastritis
,
atrophic gastritis
,
attention deficit and disruptive behavior disorders
,
impulse control disruptive and conduct disorders
,
oppositional defiant disorder
,
allergic rhinitis perennial
,
supratentorial neoplasms
,
periodontal diseases
,
furcation defects
,
kidney calculi
,
muscle relaxation
,
pancreatic fistula
,
bronchiolitis
,
surgical wound infection
,
scoliosis
,
bacterial sexually transmitted diseases
,
depressive disorder
,
schizophrenia
,
fatigue
,
psychotic disorders
,
brain injuries
,
anxiety
,
covid-19
,
coronary artery disease
,
colorectal neoplasms
,
major depressive disorder
,
traumatic brain injuries
,
musculoskeletal diseases
,
psychological stress
,
multiple sclerosis
,
cardiovascular diseases
,
mental health
,
ischemic stroke
,
bipolar disorder
,
attitudes health knowledge practice
,
alcohol drinking
,
postpartum depression
,
sclerosis
,
colonic neoplasms
,
pancreatic neoplasms
,
professional burnout
,
psychological burnout
,
inflammatory bowel diseases
,
health behavior
,
cesarean section
,
lung neoplasms
,
sleep initiation and maintenance disorders
,
exercise
,
head and neck neoplasms
,
sedentary behavior
,
frailty
,
suicide
,
drug-related side effects and adverse reactions
,
replacement arthroplasty hip
,
breast feeding
,
adenomatous polyps
,
adenoma
,
rheumatoid arthritis
,
metabolic syndrome
,
occupational stress
,
musculoskeletal pain
,
recurrence
,
maternal death
,
loneliness
,
surgical amputation
,
autistic disorder
,
cerebral palsy
,
physical fitness
,
developmental disabilities
,
respiratory distress syndrome
,
cognition
,
diarrhea
,
cognition disorders
,
psychological well-being
,
hypoxia
,
occupational diseases
,
motor activity
,
cerebral hemorrhage
,
ulcerative colitis
,
patient compliance
,
hearing loss
,
deafness
,
abscess
,
prediabetic state
,
peritonitis
,
tobacco use cessation
,
coronary disease
,
tendinopathy
,
deglutition disorders
,
smoking
,
neurologic gait disorders
,
intestinal diseases
,
sepsis
,
myocardial infarction
,
infarction
,
perinatal death
,
death
,
hypercholesterolemia
,
neurodevelopmental disorders
,
chronic renal insufficiency
,
kidney diseases
,
disease progression
,
stomach neoplasms
,
tremor
,
newborn respiratory distress syndrome
,
tic disorders
,
tinnitus
,
anterior cruciate ligament injuries
,
lupus nephritis
,
systemic lupus erythematosus
,
interstitial lung diseases
,
malaria
,
family characteristics
,
communication
,
pediatric obesity
,
essential tremor
,
epilepsy
,
mood disorders
,
suicidal ideation
,
emotional regulation
,
sarcopenia
,
obsessive-compulsive disorder
,
compulsive personality disorder
,
suicide prevention
,
sleep wake disorders
,
parasomnias
,
atrial fibrillation
,
bites and stings
,
leiomyoma
,
prostatectomy
,
ulcer
,
renal cell carcinoma
,
learning disabilities
,
polyps
,
necrosis
,
inflammation
,
sleep
,
psoriasis
,
acute disease
,
dental caries
,
postpartum hemorrhage
,
somatoform disorders
,
dyspnea
,
neuromuscular diseases
,
tobacco smoking
,
pelvic pain
,
infertility
,
non-small-cell lung carcinoma
,
personal satisfaction
,
delirium
,
artificial respiration
,
rehabilitation
,
help-seeking behavior
,
ischemia
,
pre-eclampsia
,
problem behavior
,
social isolation
,
pervasive child development disorders
,
neck pain
,
shoulder pain
,
uterine cervical neoplasms
,
bronchiectasis
,
liver cirrhosis
,
hypersensitivity
,
colonoscopy
,
myopia
,
speech intelligibility
,
attitude to health
,
coronavirus infections
,
ketosis
,
mental fatigue
,
consumer behavior
,
ataxia
,
rectal neoplasms
,
crohn disease
,
pancreatitis
,
hip injuries
,
multitasking behavior
,
acute coronary syndrome
,
cough
,
wasting syndrome
,
cachexia
,
hysterectomy
,
barotrauma
,
fibrosis
,
hypotension
,
ankle injuries
,
ankle fractures
,
ascites
,
body weight
,
body weight changes
,
panic disorder
,
social phobia
,
colonic polyps
,
maternal behavior
,
squamous cell carcinoma
,
squamous cell neoplasms
,
kidney transplantation
,
postoperative complications
,
respiratory tract infections
,
chronic disease
,
heart diseases
,
heart valve diseases
,
tuberculosis
,
motion sickness
,
bullying
,
laparoscopic cholecystectomy
,
ovarian neoplasms
,
gambling
,
sleep deprivation
,
healthy aging
,
feeding and eating disorders
,
social skills
,
athletic injuries
,
renal dialysis
,
patient participation
,
mouth neoplasms
,
gastrointestinal diseases
,
digestive system diseases
,
adolescent behavior
,
self efficacy
,
short-term memory
,
neurocognitive disorders
,
brain concussion
,
schizophrenia spectrum and other psychotic disorders
,
movement disorders
,
cerebral small vessel diseases
,
down syndrome
,
nurse's role
,
heat stress disorders
,
hyperthermia
,
adolescent psychiatry
,
dyssomnias
,
cystic fibrosis
,
pregnancy complications
,
physician-patient relations
,
central serous chorioretinopathy
,
ultrasonography
,
abdominal neoplasms
,
cutaneous fistula
,
laryngectomy
,
obstetric labor
,
myofibroma
,
hip osteoarthritis
,
brachial plexus block
,
colonic diseases
,
parturition
,
colitis
,
liver transplantation
,
immunologic deficiency syndromes
,
antibiotic prophylaxis
,
precursor cell lymphoblastic leukemia-lymphoma
,
lymphoid leukemia
,
systemic scleroderma
,
music therapy
,
auditory perception
,
rotator cuff injuries
,
femoracetabular impingement
,
joint dislocations
,
diabetes complications
,
diabetic foot
,
peripheral nervous system diseases
,
foot ulcer
,
sleep quality
,
dyslipidemias
,
decision support techniques
,
myeloid leukemia acute
,
barrett esophagus
,
bursitis
,
abdominal injuries
,
drug interactions
,
pharmacological phenomena
,
rotator cuff tear arthropathy
,
osteonecrosis
,
executive function
,
amniotic fluid embolism
,
psoriatic arthritis
,
appendicitis
,
rupture
,
acute cholecystitis
,
cholecystitis
,
acalculous cholecystitis
,
obstructive jaundice
,
jaundice
,
stomatognathic diseases
,
postoperative care
,
male breast neoplasms
,
stable angina
,
hemorrhagic stroke
,
rheumatic diseases
,
collagen diseases
,
mobility limitation
,
amyotrophic lateral sclerosis
,
motor neuron disease
,
dysarthria
,
aspiration pneumonia
,
axial spondyloarthritis
,
student dropouts
,
nervous system diseases
,
phantom limb
,
physiologic monitoring
,
endometriosis
,
endoscopic retrograde cholangiopancreatography
,
anesthesia recovery period
,
rib fractures
,
thoracic injuries
,
olfaction disorders
,
dysgeusia
,
prenatal care
,
mesenteric ischemia
,
intraabdominal infections
,
sensitivity training groups
,
professional-patient relations
,
accidental injuries
,
patient care
,
bilateral hearing loss
,
hospitalization
,
emotions
,
hiv testing
,
treatment-resistant schizophrenia
,
pregnancy in adolescence
,
transient ischemic attack
,
secondary prevention
,
obstetric labor complications
,
infant mortality
,
eclampsia
,
status epilepticus
,
sarcoma
,
nonvital tooth
,
psychomotor agitation
,
transcutaneous electric nerve stimulation
,
thyroid diseases
,
shoulder impingement syndrome
,
perfectionism
,
iron-deficiency anemia
,
iron deficiencies
,
postpartum period
,
respiration disorders
,
muscular dystrophies
,
craniofacial abnormalities
,
arthrogryposis
,
metabolism
,
circulating neoplastic cells
,
behavior and behavior mechanisms
,
tooth loss
,
edentulous jaw
,
edentulous mouth
,
psychology biofeedback
,
neuroendocrine tumors
,
disease
,
patient acceptance of health care
,
peroneal neuropathies
,
paresis
,
gastrostomy
,
blood pressure
,
test anxiety
,
fragile x syndrome
,
cerebellar ataxia
,
sars-cov-2
,
acute lung injury
,
feasibility studies
,
inhalation administration
,
drug delivery systems
,
dentistry
,
venous insufficiency
,
noise-induced hearing loss
,
food preferences
,
cell phone use
,
attempted suicide
,
dyskinesias
,
magnetic resonance imaging
,
cognitive aging
,
infant death
,
staphylococcal infections
,
staphylococcus aureus
,
facies
,
racism
,
generalized anxiety disorder
,
risk reduction behavior
,
hematologic neoplasms
,
heart arrest
,
post-cardiac arrest syndrome
,
water supply sanitary surveys
,
congenital hip dislocation
,
hip dislocation
,
developmental dysplasia of the hip
,
soft tissue injuries
,
limb salvage
,
diverticular diseases
,
diverticulitis
,
colonic diverticulitis
,
diverticulum
,
patient discharge
,
self-injurious behavior
,
maxillofacial injuries
,
cholecystectomy
,
hereditary nonpolyposis colorectal neoplasms
,
hereditary breast and ovarian cancer syndrome
,
ovariectomy
,
bronchopulmonary dysplasia
,
cardiorespiratory fitness
,
bipolar and related disorders
,
aortic valve stenosis
,
pathologic constriction
,
muscle weakness
,
patient reported outcome measures
,
neglected diseases
,
psychological dependency
,
hypoglycemia
,
borderline personality disorder
,
personality disorders
,
shame
,
visual acuity
,
asthenopia
,
color perception
,
post-exercise hypotension
,
perinatal mortality
,
spinocerebellar degenerations
,
spinocerebellar ataxias
,
hepatitis b
,
intellectual disability
,
ovarian epithelial carcinoma
,
plantar fasciitis
,
cooperative behavior
,
hand hygiene
,
cocaine-related disorders
,
congenital abnormalities
,
bundle-branch block
,
heart block
,
microvascular angina
,
squamous cell carcinoma of head and neck
,
urinary tract infections
,
osteomyelitis
,
meningitis
,
bacteremia
,
cellulitis
,
enteritis
,
dehydration
,
gastroenteritis
,
sexual behavior
,
intestinal perforation
,
abdominal aortic aneurysm
,
aortic aneurysm
,
aortic diseases
,
voice disorders
,
hyperekplexia
,
catheters
,
infantile diarrhea
,
urinary retention
,
seizures
,
presbyopia
,
spondylolisthesis
,
procedural pain
,
multidrug-resistant tuberculosis
,
renal colic
,
morphine dependence
,
urolithiasis
,
thrombosis
,
literacy
,
psychotic affective disorders
,
social psychology
,
osteoporosis
,
immobilization
,
kinesiophobia
,
postcholecystectomy syndrome
,
biliary tract diseases
,
arterial occlusive diseases
,
extracorporeal circulation
,
stroke rehabilitation
,
memory
,
autologous blood transfusion
,
acute necrotizing pancreatitis
,
healthy diet
,
hyperkinesis
,
high-energy shock waves
,
neurogenic urinary bladder
,
psychosocial functioning
,
knee injuries
,
reinjuries
,
hydrothorax
,
papilloma
,
excoriation disorder
,
esophageal achalasia
,
esophagitis
,
lung injury
,
physical therapy modalities
,
pregnancy rate
,
lichen planus
,
precancerous conditions
,
leukoplakia
,
gastrointestinal endoscopy
,
immediate hypersensitivity
,
affect
,
physiological stress
,
cross infection
,
activities of daily living
,
treatment outcome
,
occupational therapy
,
skin neoplasms
,
liver diseases
,
poliomyelitis
,
reproductive behavior
,
contraception behavior
,
mindfulness
,
joint instability
,
shoulder dislocation
,
therapeutic alliance
,
nurse-patient relations
,
empathy
,
hypoventilation
,
inferior wall myocardial infarction
,
thoracic neoplasms
,
child behavior
,
parenting
,
parent-child relations
,
osteochondrosis
,
deep brain stimulation
,
forensic psychiatry
,
hypothermia
,
malignant hyperthermia
,
pressure ulcer
,
crush injuries
,
nursing care
,
muscle spasticity
,
aortic valve disease
,
mitral valve insufficiency
,
nephrectomy
,
addictive behavior
,
internet addiction disorder
,
prolonged grief disorder
,
absenteeism
,
femoral neck fractures
,
long-term care
,
huntington disease
,
consensus
,
mediterranean diet
,
binge drinking
,
health education
,
goals
,
orientation
,
personality
,
leadership
,
war-related injuries
,
urinary incontinence
,
stress urinary incontinence
,
enuresis
,
cumulative trauma disorders
,
medically unexplained symptoms
,
chronic kidney disease-mineral and bone disorder
,
plyometric exercise
,
post-concussion syndrome
,
clinical decision rules
,
procrastination
,
mother-child relations
,
recreational drug use
,
social marginalization
,
basal cell carcinoma
,
basal cell neoplasms
,
pulmonary fibrosis
,
trauma and stressor related disorders
,
progressive bulbar palsy
,
prostheses and implants
,
heart disease risk factors
,
fever
,
heat stroke
,
body temperature regulation
,
social behavior
,
smoking reduction
,
spontaneous abortion
,
neurodegenerative diseases
,
contraceptive effectiveness
,
resuscitation
,
lipedema
,
central nervous system sensitization
,
alcohol-related disorders
,
digestive system neoplasms
,
adenocarcinoma
,
glandular and epithelial neoplasms
,
occlusal splints
,
pregnancy-induced hypertension
,
muscle strength
,
exercise therapy
,
postural balance
,
posture
,
ocular vision
,
attention
,
separation anxiety
,
agoraphobia
,
thyroiditis
,
constipation
,
diabetic retinopathy
,
antisocial personality disorder
,
critical care
,
pilot projects
,
gallstones
,
cholelithiasis
,
cholecystolithiasis
,
choledocholithiasis
,
preoperative care
,
elective surgical procedures
,
smoldering multiple myeloma
,
endometrial neoplasms
,
menorrhagia
,
uterine hemorrhage
,
adjustment disorders
,
uterine prolapse
,
prolapse
,
univentricular heart
,
visual perception
,
eye movements
,
psychomotor performance
,
lactose intolerance
,
ventilator-associated pneumonia
,
chronic brain injury
,
celiac disease
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